Epocrates, Inc. Announces Pricing of Initial Public Offering

February 2, 2011

San Mateo, CA — Epocrates, Inc. (NASDAQ: EPOC) today announced the pricing of the initial public offering of 5,360,000 shares of its common stock at a price to the public of $16.00 per share. The shares are expected to begin trading today on the NASDAQ under the ticker symbol “EPOC”. Epocrates is offering 3,574,285 shares and selling stockholders are offering the remaining 1,785,715 shares. In addition, the underwriters have been granted a 30-day option to purchase up to an addtional 804,000 shares of common stock from Epocrates to cover over-allotments, if any. Epocrates will not receive any proceeds from the sale of shares by the selling stockholders.

J. P. Morgan Securities LLC and Piper Jaffray & Co. are serving as joint book-running managers. William Blair & Company, L.L.C. and JMP Securities LLC are acting as co-managers.

A registration statement relating to this offering was declared effective by the Securities and Exchange Commission on February 1, 2011. This offering is being made solely by means of a written prospectus, a copy of which my be obtained from J. P. Morgan Securities LLC, c/o Broadridge Financial Solutions, 1155 Long Island Ave., Edgewood, NY 11717, or by calling 1-866-803-9204, or from Piper Jaffray & Co., 800 Nicollet Mall, Suite 800, Minneapolis, MN 55402, or by calling 1-800-747-3924 or sending an email to prospectus@pjc.com.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

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